Cellular Immunity in COVID-19 Convalescents with PCR-Confirmed Infection but with Undetectable SARS-CoV-2–Specific IgG
نویسندگان
چکیده
Abstract We investigated immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among a group of convalescent, potential blood donors in Germany who had PCR-confirmed SARS-CoV-2 infection. Sixty days after onset symptoms, 13/78 (17%) study participants borderline or negative results to an ELISA detecting IgG the S1 protein SARS-CoV-2. analyzed with infection strong antibody (ratio >3) as positive controls and without symptoms household contact infected patients controls. Using interferon-γ ELISpot, we observed that 78% PCR-positive volunteers undetectable antibodies showed T cell immunity similar frequency (80%) T-cell convalescent but did not detect concluded that, IgG, may be mediated through cells.
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ژورنال
عنوان ژورنال: Emerging Infectious Diseases
سال: 2021
ISSN: ['1080-6059', '1080-6040']
DOI: https://doi.org/10.3201/2701.203772